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Mesenchymal stem cells for osteoarthritis treatment
Mesenchymal stem cells for osteoarthritis treatment (Belarus)

Mesenchymal stem cells for osteoarthritis treatment

Osteoarthritis (OA) is the most pressing problem of orthopedics and rheumatology. The existing treatment methods are not able to effectively stop the process of cartilage degeneration, but only slow it down, improving for a certain time the clinical and functional state of the affected joint. The disease progression leads to significant joint function reduction, patient disability, and the need of joint replacement surgery.

A new trend in OA treatment is the mesenchymal stem cells application. The regenerating effect of MSC is due to their structural contribution to tissue repair, as well as immunomodulatory and anti-inflammatory action due to the secretion of bioactive molecules. However, the use of a patient’s own MSC has a number of limitations. It has been established that the number of MSCs and their activity decreases with age and is difficult to obtain a sufficient and effective MSC graft in patients over 40 y.o., who most often suffer from OA. In this regard, the possibility of donor MSCs using has been studied: MSCs have low immunogenicity, since these cells do not have HLA class II antigens - that eliminates the risk of cell rejection.

Indications:

  • OA grade I-II, II, II-III (Kellgren-Lawrence radiological classification)

Contraindications:

  • Joint and surrounding skin infectious

Goals:

  • Decrease pain
  • Increase joint function
  • Reduce medications reception
  • Delay/cancel surgery

Procedure:

  • Single intra-articular injection under ultrasound control

Graft composition: Cellular materials are MSCs of healthy donors from a stem cells bank. MSC are expanded to the required amount over 20 million cells and injected into the affected joint in a matrix of hyaluronic acid. If possible (for young patients) own stem cells can be used – it requires 2 steps procedure because of 4 weeks cells cultivation period.

Our clinical trials showed a persistent pain reduction and joint function improvement  in 80% of patients in a year after MSC application.

This method is approved by Ministry of Public Health of the Republic of Belarus.

The estimated cost of Mesenchymal Stem Cells graft is about $ 2500.

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