Загрузка страницы
Mesenchymal stem cells for full thickness joint cartilage lesions
Mesenchymal stem cells for full thickness joint cartilage lesions (Belarus)

Mesenchymal stem cells for full thickness joint cartilage lesions

Local full-thickness lesions of articular cartilage can be the result of trauma or disease. These lesions are located within the cartilage or involve the underlying subchondral bone.

In absence of adequate treatment, a defect remains at the injury site or it is filled with a connective tissue scar, which cannot adequately transfer the loads on the joint. The patient has  pain, the joint functionality is reduced. As a result, an early osteoarthritis of the entire joint occurs. In the long term the progression of the disease may lead to perform joint replacement.

It is known that mature hyaline cartillage has an extremely low regenerative potential. In this regard, the most promising direction of cartilage defects repair is the transplantation of cells capable for chondrogenesis, i.e. the formation of cartilage tissue. For these purposes, mesenchymal stem cells are suitable.

The method is based on a proven idea of MSCs ability to transform into cartilage cells under control of certain environmental factors. Thus, if we select MSC from a patient, then increase their number and place them into existing cartilage defect, then it can be filled by regenerative tissue similar to the surrounding articular cartilage.

In RSPC for Traumatology and Orthopedics a new method for full-thickness cartilage lesions repair has been developed. For transplantation we use cultivated patient's bone marrow MSC. The method is most suitable for knee joint cartilage injuries treatment.

Indications:

  • Traumatic lesions of articular cartilage
  • Chronic lesions of articular cartilage
  • Osteochondritis dissecans

It’s preferred to fill defects larger than 3 cm2

Contraindications:

  • More than two cartilage defects or multiple (including "kissing") defects
  • Systemic immune diseases with joint damage
  • Joint infections
  • Joint instability
  • Axial deformations of the joint more than 10 °

Procedure:

Step I:  Arthroscopic joint examination, determination of defect size to be filled. At the same time - pelvic crest puncture and 40-100 ml bone marrow aspiration.

Step II: The bone marrow is delivered to the cell laboratory. Mesenchymal stem cells are selected and expanded, their number is increased to 10-40 millions. Control of cells sterility and immunophenotype is carried out. Laboratory cultivation period lasts for 4-5 weeks.

Step III: Surgical MSC graft transplantation directly into the joint cartilage defect.

In the postoperative period, walking with crutches without weight bearing for 1–1.5 months can be recommended.

MRI of patient with osteochondritis dissecans before and 2 years after surgery
MRI of patient with osteochondritis dissecans before and 2 years after surgery

Advantages of the method:

  • Allows to fill the cartilage defect with regenerative tissue similar to the surrounding hyaline cartilage;
  • Safety - application the patient’s own stem cells;
  • Low invasive - a small surgical approach is used for transplantation (3-4 cm);
  • Effectiveness - clinical studies have shown a significant reduction or disappearance of pain in the joint, a significant improvement of joint function in all patients.

This method is approved by Ministry of Public Health of the Republic of Belarus.

The estimated cost of Mesenchymal Stem Cells graft is about $ 2500.

20
6000
670
8800
Наш сайт использует анонимные данные, передаваемые при помощи файлов cookie.
С нашей политикой в отношении обработки персональных данных вы можете ознакомиться по ссылке.
Чтобы отказаться от файлов cookie, воспользуйтесь соответствующими настройками своего браузера.
Принять